T-lymphocytes activation and expression of costimulatory molecules in human toxoplasmosis during pregnancy
Benha Medical Journal. 2007; 24 (1): 479-489
en Inglés
| IMEMR
| ID: emr-168559
ABSTRACT
The study was carried on 48 pregnant patients with positive sera for Toxoplasma antibodies [IgG, IgM] and 12 cross matched healthy control pregnant women. All studied cases were submitted to flow cytometric analysis of peripheral blood mononuclear cells [PBMNCs]; using monoclonal antibodies [MAbs] against CD3, CD4, CD8, CD28 and HLA-DR. Results revealed that, there was a significant decrease in CD4 and the expression of co stimulatory molecule CD28 on CD8 T lymphocytes, while the activation marker HLA-DR expression on CD4 T lymphocytes was significantly increased, but the changes in CD3 and CD8 T lymphocytes were insignificant
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Humanos
/
Embarazo
/
Linfocitos T
/
Antígenos HLA-DR
/
Antígenos CD4
/
Antígenos CD8
/
Complejo CD3
/
Antígenos CD28
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Benha Med. J.
Año:
2007
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