T-Lymphocyte subsets in early schistosomal cancer bladder

ABSTRACT

T-lymphocytes were claimed to have important role in the immunopathogenesis of schistosomal bladder cancer. In the present study a trial was made to assess T-lymphocyte level and its subsets for diagnosing early bladder cancer in schistosomal patients. The work included 20 cases divided into two equal groups; the first included patients with Schistosoma haematobium while the second included patients with schistosomal bladder cancer. In addition, 10 healthy subjects were also included as controls. In all 3 groups active T-cells count was performed using the Rosette test and the T-lymphocyte subsets were evaluated by the monoclonal antibody test using the immunofluorescent technique. Active T-cells were found to be significantly elevated in both studied groups with significant difference in between. The elevation was more significant in group II. T-helper cells were also statistically elevated in group I and II but with no significant difference. Suppressor cells were only elevated in cases with schistosomal cancer bladder. A significant positive correlation was observed between helper and suppressor cells in the two studied groupos as well as in controls