Spinal anaesthesia; comparison between prophylactic low dose ketamine and ondansetron for prevention of shivering during spinal anaesthesia in patients undergoing lower abdominal surgeries

ABSTRACT

Perioperative shivering is a common problem during spinal anaesthesia. It causes tremendous deleterious effects on metabolism of body. Despite of re-warming and raising the ambient temperature, several drugs are under research to evaluate their preventive role in shivering during anaesthesia like tramadol, butorphanol, midazolam, ketamine and ondansetron. The present study was conducted to evaluate the effect of prophylactic low dose ketamine and ondansetron for prevention of shivering during spinal anaesthesia. To compare prophylactic low dose ketamine with ondansetron for prevention of shivering during spinal anaesthesia in patients undergoing lower abdominal surgeries. Randomized controlled trial. Department of Anaesthesia, Nishtar Hospital Multan. November 2012 to May 2013. A total of 256 patients were included in the study divided into two equal groups. In this study basic demographics like age, gender, mean weight and height and type of surgery patients underwent were similar, having no significant difference in both groups, while on comparison in both groups, the frequency of shivering revealed 4.69%[n=6] in K Group and 11.72%[n=15] in O Group while remaining 95.31%[n=122] in K and 88.28%[n=113] in O Group had no findings of the morbidity, p value was calculated as 0.03, which showed significant difference. The result of the study concluded that prophylactic intravenous administration of low dose ketamine [0.25mg/kg] is significantly more effective than ondansteron [4 mg] for prevention of shivering during spinal anesthesia in patients undergoing lower abdominal surgeries