[Effect of magnesium sulfate on bleeding time in pregnancy]

ABSTRACT

According to some studies, pharmacological concentrations of Mg[2+] have anti-thrombotic effects and interfere with platelet aggregation in vitro and in vivo. The study group consisted of 50 pregnant women who required magnesium sulfate for mild pre-eclampsia or preterm labor. In all patients, a platelet count, magnesium level, bleeding time and mean arterial pressure were obtained before and 2 hours after magnesium sulfate infusion. Magnesium sulfate was started with a 6 gr intravenous bolus, followed by 2 gr/hr infusion. Bleeding time was measured by Duke Method. Data were analyzed with Mann Whitney U and Wilcoxon rank tests. Thirty one patients [62%] received magnesium sulfate for preterm labor and 19 [38%] for mild pre-eclampsia. Analysis of the entire study group revealed a rise in the magnesium level [p<0.0001], a lowering of the mean arterial pressure [p<0.0001] and no significant difference of the bleeding time and platelet count. Comparison of platelet count, magnesium level and bleeding time before and 2 hours after magnesium sulfate infusion revealed no significant difference in two groups. According to this study, magnesium sulfate with usual dosage has no effect on bleeding time in pregnancy