effect of six weeks-voluntary wheel running on brain amyloid beta [1-42] levels of diabetic rats

ABSTRACT

Amyloid Beta [1-42] is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta [1-42] in the diabetic rats induced with alloxan. 28 male rats weight 185 +/- 1 were assigned randomly to 4 groups [N=7] normal control [C], training [T], control-diabetic [CD] and diabetic-training [DT]. Diabetes was induced with injecting Alloxan [120 mg/kg dissolved in saline] intraperitoneal. 6 weeks of voluntary wheel running decreased the cortex A beta [1-42] in T and DT groups. A beta [1-42] levels significantly decreased in the T and DT in compare with C and CD [p<0.001], respectively. Also A beta [1-42] levels significantly increased in the CD in compare with C [p<0.001]. Voluntary exercise had positive effects on decreasing of A beta [1-42] levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes