Effect of partial sleep deprivation on lipid profile in high fat diet-fed rats in the presence and absence of vitamin C

ABSTRACT

The daily stress and shift working cause insomnia. In other hands, fatty food consumption increased this disorder. The aim of present study is evaluation additive effect of partial insomnia and high fatty diet with or without vitamin C on serum lipid profile in rats. Fifty six rats in 7 groups [8 rats each group] were conducted for study during 26 days as 1 normal diet+normal sleep, 2 high fatty diet+normal sleep, 3 normal diet+insomnia, 4 high fatty diet+insomnia, 5 high fatty diet+normal sleep+vitamin C, 6 high fatty diet+insomnia+vitamin C, 7 normal diet+insomnia+ vitamin C. The lipid profile was examined at end of study. Results shown the high fatty diet+insomnia increased triglyceride, LDL, VLDL level and decreased HDL level with comparison to high fatty diet+normal sleep group. But only insomnia did not change serum lipid profile. High fatty diet increased level of cholesterol [p<0.05]. The normal diet increased body weight but high fatty diet decreased it significantly. Liver weight ratio was elevated by high fatty diet+insomnia. The vitamin C decreased cholesterol and increased HDL level in group of rats which received high fatty diet+insomnia. In conclusion, the present study shown the only insomnia did not affect on serum lipid profile while insomnia along with high fatty diet increased lipid high risk factors in blood