Evaluation of the role of CXCL8 and NOx in pediatric type 1 diabetes mellitus

ABSTRACT

Genetic and environmental factors may play a role in the etiology of type 1diabetes [T1D] but a well-accepted view is that autoimmunity is the predominant effector. The aim of this study is to investigate the profile and the relationships between interleukin [IL, CXCL] -8 and nitric oxide metabolite [NOx] in T1D and to reveal their possible role in the development and progression of the disease and its complications. Twenty children with Type 1 diabetes [T1D] were enrolled for the study and compared to twenty healthy age and gender matched non-diabetic controls. The data revealed that children with T1D established high glycated hemoglobin [HbA1c%] values versus the control group [P<0.0001]. Significantly higher serum CXCL-8 concentration [23.54 +/- 11.92pg/ml] was detected in T1D children versus the control group [5.69 +/- 1.67pg/ml]. On the other hand, serum nitric acid metabolite [NOx] showed a significant reduction in the T1D children [2.38 +/- 1.14 mmol/l] compared to the control group [4.63 +/- 1.2 mmol/l]. Correlation analysis showed positive correlation between CXCL-8 with duration of the diabetes and with HbA1c. It could be concluded that CXCL-8 and NO may play important roles in the pathophysiology and progression of T1D with increased possibility to develop premature atherosclerosis which should be considered in the development of new strategies for monitoring the disease as well as for developing effective preventive and therapeutic interventions: