Factor V and VIII inhibitor in patients with combined factor v and VIII deficiency

ABSTRACT

Patients with coagulation factor[s] deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor[s]. In this survey we detected factor V and VTQ inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran [Khorassan province]. It was revealed in our survey that eight patients had both factor V and factor VIII inhibitors and two patients had none. Because factor V and factor VIII share approximately 40% amino acid sequence homology in their A and C domains, it remains to be elucidated if it is one molecule that recognizes both factor V and VIII or whether there are two inhibitor molecules against common sites