Interleukin-10 level in occult hepatitis C virus infection in hemodialysis patient

ABSTRACT

Interleukin 10 is a critical immunoregulatory molecule, produced mainly by macrophage, Th2 and regulatory T cells, is a potent immunosuppressive cytokine with anti-inflammatory activity. Detection of the serum level of IL-10 in OCI in HD patients. 75 HD patients from HD units in Assiut university Hospital, were enrolled in this study, and IL-10 were measured in 8 patients with OCI, 68 HD without OCI and 10 normal subjects as a control. The level of IL-10 was highly significantly increased in HD patient with OCI than in HD patients without OCI [P< 0.001], and in HD patients than normal subject [P<0.001] There is significant increase as regarding ALT [P<0.001], AST [P< 0.001], in occult HCV infection in HD patients. Our data revealed a high serum level of IL-10 in occult HCV infection in HD patients with persistently abnormal elevated levels of liver enzymes than HD patients without OCI