Improving the dissolution rate of water-insoluble drugs by surface adsorption

ABSTRACT

Solvent deposition triturations of flufenamic acid and chlorpropamide on aerosil 200 were prepared using acetone as equilibrating solvent. The surface adsorption of the two drugs on the selected carrier markedly increased the drug dissolution. After 10 minutes complete dissolution of flufenamic acid was achieved at equal concentrations of the drug and aerosil, while only 56% of chlorpropamide was released from the trituration containing 12 drug aerosil ratio. On the other hand 18 and 11% of the pure flufenamic acid and chlorpropamide respectively was released after 10 minutes. The solvent deposition triturations of both drugs were wet granulated and compressed separately into tablets. Evaluation of the prepared tablets showed that aerosol greatly affected the mechanical properties, disintegration time and dissolution rate. Tablets containing aerosil exhibited rapid disintegration time and high dissolution rates