Serotonin Receptor Antagonists Nan-190, Methiothepin, Methysergide, Mianserin Or Ondansetron protect against Methamphetamine-Induced Hyperthermia in mice

ABSTRACT

The effect of some serotonin receptor antagonists was investigated on the body temperature of male mice. These antagonists produced significant reductions of body temperature in methamphetamine-induced hyperthermic male mice. Thus, the hyperthermia induced by metha-mphetamine [11 mol/kg,i.p..] was antagonized by the previous i.p. administration of 1.06 Amol/kg NAN-190 [5-HTIA receptor antagonist], 22.1 Amol/kg methiothepin [5-HT IB/ID receptor antagonist], 2.13 iimol/kg methysergide [5-HT 2,v2B receptor antagonist], 3.3 ktmol/kg mianserin [5-HT2c and a2 - adrenoceptor antagonist] or 0.003 Amol/kg ondansetron [5-HT3 receptor antagonist]. The present results indicate that central serotonin receptors may he involved in the hyperthermic effect of methamphetamine. Ondansetron, being effective at a relatively small dose [0.003 Amol/kg] as compared to other antagonists used in this study, may be a potential antidote for methamphetamine-induced hyperthermia