Study of the pathophysiological mechanism in patients with typical chest pain and normal coronary arteries

ABSTRACT

Endothehelial dysfunction. thrombogenesis and inflammation were studied as possible mechanisms in pathogertesis of cardic syndrome-X through monitoring plasma endothelin-1 fibrinogen, vWF and CRP in patients with typical chest pain, positive stress ECG[clinical and ECG evidence of ischemia] and normal coronary angiography. The aim of this study is to evaluate plasma concentration of enclothelin-1 and other factors in patients with typical angina pectoris and angiographically normal coronary arteries. This study included 50 patients complained of typical chest pain [group A], Another group of 20 healthy subjects were studied as control group [group B]. Exercise test and coronary angiography were performed for all patients. Patients showing positive exercise ECG and having normal coronary arteries were selected. Blood samples were collected and examined for endothelin-1, fibrinogen, CRP and vWF. Endotheline-l fibrinogen, CRP and vWF were found to be significantly raised in that group of patients with syndrome-X in comparison with the control group, so they could predict and confirm diagnosis in patients with syndrome-X. CRP, vWF fibrinogen and ET-1 in that order were significantly high in patients with syndrome-X. Thus assessment of their levels in serum may be highly needed to fulfill the diagnosis of cardiac syndrome-X