Clinical, biochemical and electromyographic studies in muscle diseases in infancy and childhood

ABSTRACT

The study included 49 cases suspected of having muscle disease and the initial clinical was confirmed by investigations in 42 cases [84%]. In 7 cases [14%], electromyography and enzyme studies [CPK, aldolase, L.D.H., L.D.H. isoenzymes and choline-estrase] were essential for final diagnosis. Creatinep hosphokinase levels are more markedly increase in cases of muscular dystrophy and the levels have positive correlation with the duration of the disease. Lactic dehydrogrenase showed more definite rise than serum aldolase in cases of muscular dystrophy. Serum levels over 1500 I.U/L were encountered only in cases of muscular disease as well as permitting early diagnosis. Serum choline-estrase showed no significant change in all cases and this means that is still no positive evidence of presence of a relationship between the neurotransmitter and muscle disease