Urinary markers for early detection of Diabetic Nephropathy in type 1 Diabetes Mellitus
Egyptian Journal of Hospital Medicine [The]. 2015; 61 (October): 479-488
en Inglés
| IMEMR
| ID: emr-173905
ABSTRACT
Background:
diabetic nephropathy [DN] is a serious complication of diabetic mellitus associated with increased risk of morbidity and mortality. Diagnostic markers to detect DN at early stage are important as early intervention can slow loss of kidney functions and improve patient outcomes. N-acetyl Beta d-glucosaminidase [NAG] is a lysosomal enzyme, present in high concentrations in renal proximal tubular cells, Gamma-glutamyltransferase [GGT] is an enzyme which located along the proximal tubular brush border, Malondialdehyde [MDA] is a highly toxic product, formed in part by lipid oxidation derived free radicals, Reactive carbonyl derivatives [RCD[S]] is an oxidative stress marker in urine, as a measure of the oxidative modification of proteins and beta-2-microglobulin is filtered by the glomerulus, absorbed and catabolized by the proximal tubules. The aim of this study is to investigate the urinary outcome of these markers as early detectors of diabetic nephropathy in type 1 diabetic children
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Acetilglucosaminidasa
/
Microglobulina beta-2
/
Estrés Oxidativo
/
Diabetes Mellitus Tipo 1
/
Gamma-Glutamiltransferasa
/
Malondialdehído
Tipo de estudio:
Estudio de tamizaje
Límite:
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Egypt. J. Hosp. Med.
Año:
2015
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