Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals

ABSTRACT

Objective/Background: MicroRNAs [miRNAs] play an important role in diseases development. Therefore, human miRNAs may be able to inhibit the survival of Mycobacterium tuberculosis [Mtb] in the human host by targeting critical genes of the pathogen. Mutations within miRNAs can alter their target selection, thereby preventing them from inhibiting Mtb genes, thus increasing host susceptibility to the disease