Role of oxidative stress in modulating unfolded protein response activity in chronic myeloid leukemia cell line

ABSTRACT

Background: Recently, it has been revealed that tyrosine kinase inhibitors [TKIs] act through inducing both oxidative and endoplasmic reticulum [ER] stress in chronic myeloid leukemia cells. However, ER stress signaling triggers both apoptotic and survival processes within cells. Nevertheless, mechanisms by which TKIs avoid the pro-survival effects are not clear. The aim of this study was to evaluate the potential role of oxidative stress in activity of unfolded protein response [UPR] survival pathway within K562 cell line