Th1 and Th2 cytokine gene polymorphism in Iranian patients with chronic myelogenous leukemia
IJI-Iranian Journal of Immunology. 2004; 1 (1): 26-33
en Inglés
| IMEMR
| ID: emr-174281
ABSTRACT
Bakground lt has been hypothesized that genetic factors other than histocompatibility disparity may play a role in predisposition to developing Chronic Myelogenous Leukemia [CML]. In this regard, Thl and Th2 cytokines and their gene polymorphism seems to be important. Overall expression and secretion of cytokines is dependent, at least in part, on genetic polymorphism [nucleotide variations] within the promoter region or other regulatory sequences of cytokine genes. The majority of polymorphisms described are single nucleotide polymorphism [SNPs]. The objective of this study was to analyze the genetic profile of Thl and Th2 cytokines in 30 Iranian patients with CML and 40 healthy subjects:
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Índice:
IMEMR (Mediterraneo Oriental)
Idioma:
Inglés
Revista:
Iran. J. Immunol.
Año:
2004
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