IJFS-International Journal of Fertility and Sterility. 2016; 9 (4): 436-441
en En
| IMEMR
| ID: emr-174826
Biblioteca responsable:
EMRO
Background: The aim of this study was to evaluate the efficacy and safety of a recombinant human follicle stimulating hormone [r-FSH] low-dose step-up regimen for controlled ovarian hyperstimulation in patients undergoing ovulation induction [OI] with intrauterine insemination [IUI]
Materials and Methods: The study was conducted in the Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan. In this prospective, observational study, consecutive infertile women [20-35 years] with regular menstrual cycles and a normal baseline FSH level were prospectively enrolled between January 2010 and September 2010. A starting dose of 112.5 IU/day r-FSH was administered on day 3 and increased by 37.5 IU/day every 2 days until a follicle >/= 11 mm in diameter was present. Recombinant human chorionic gonadotropin [r-hCG] was administered when a follicle >/= 18 mm was noted. Monifollicular development was defined as only one follicle with a diameter >/= 16 mm. Clinical pregnancy was defined as a pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs
Results: A total of 29 women and 30 cycles were included. The mean daily dose of r-FSH to achieve a follicle of >/= 11 mm in diameter was 131.3 +/- 23.6 IU and the mean total dose was 1030.0 +/- 383.2 IU. Approximately 41% of the cycles were monofollicular. Clinical pregnancy was observed in 9 [30.0%] cycles, and a fetal heart beat was observed in 7 [23.3%]. There were no multiple pregnancies. Mild ovarian hyperstimulation syndrome, which was resolved with conservative management, was observed in 3 [10.0%] cycles
Conclusion: This r-FSH low-dose step-up regimen seems to be a feasible and practical method for OI in younger infertile women undergoing IUI
Materials and Methods: The study was conducted in the Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan. In this prospective, observational study, consecutive infertile women [20-35 years] with regular menstrual cycles and a normal baseline FSH level were prospectively enrolled between January 2010 and September 2010. A starting dose of 112.5 IU/day r-FSH was administered on day 3 and increased by 37.5 IU/day every 2 days until a follicle >/= 11 mm in diameter was present. Recombinant human chorionic gonadotropin [r-hCG] was administered when a follicle >/= 18 mm was noted. Monifollicular development was defined as only one follicle with a diameter >/= 16 mm. Clinical pregnancy was defined as a pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs
Results: A total of 29 women and 30 cycles were included. The mean daily dose of r-FSH to achieve a follicle of >/= 11 mm in diameter was 131.3 +/- 23.6 IU and the mean total dose was 1030.0 +/- 383.2 IU. Approximately 41% of the cycles were monofollicular. Clinical pregnancy was observed in 9 [30.0%] cycles, and a fetal heart beat was observed in 7 [23.3%]. There were no multiple pregnancies. Mild ovarian hyperstimulation syndrome, which was resolved with conservative management, was observed in 3 [10.0%] cycles
Conclusion: This r-FSH low-dose step-up regimen seems to be a feasible and practical method for OI in younger infertile women undergoing IUI
Buscar en Google
Índice:
IMEMR
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
Int. J. Fertil. Steril.
Año:
2016