Effect of nanosilver particles on Procaspase-3 expression in newborn rat brain

ABSTRACT

Objective: Nanotechnology focuses on materials having at least one dimension of less than 100 nanometers. Nanomaterials such as Nanosilver [NS] have unique physical and chemical properties such as size, shape, surface charge. NS particles are thought to induce neuronal degeneration and necrosis in the brain. It has been reported that NS particles generate free radicals and oxidative stress which alters gene expression and induces apoptosis. This study was designed to evaluate whether the detrimental effect of NS particles is through the activation of Procaspase-3 during fetal neural development