Impacts on the third line of defense specialized against microbial infection as a result of exposure to gamma-radiation

To understand the toxicity and the potential role of gamma-radiation [GR] as a therapeutic tool, the effects of different GR doses on haematological and dimensional properties of rats' blood were investigated in vivo. 60 healthy male Wistar-Kyoto rats were used in this study, and were randomly divided into 5 groups, 4GR rat groups [1St group was radiated with 5GR, 2nd group 25Gy; 3rd group with 50Gy, 4th group with 100Gy and 5th group was the control]. Different haematological and dimensional parameters were measured using the standard haematological technique for complete blood count [CBC]. A significant decrease in white blood cells [WBCs] count and lymphocytes [LYM] was observed compared with the control. While a significant increase in monocytes [MON], neutrophils [NEU], basophils [BAS], and eosinophils [EOS] were observed. A non-significant decrease in platelets [PLTs] count was observed with GR compared with the control