[Factors associated with Cyclosporine A-induced gingival enlargement in kidney transplant patients]

Background and Aim: Cyclosporine-A [CsA] is commonly prescribed for kidney transplant patients to suppress their immune systems, which can lead to gingival enlargement [GE]. The present study aimed at determining the prevalence of associated factors with CsA-induced gingival enlargement in kidney transplant patients in Rasht during 2012

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Materials and Methods: In this cross sectional research, information about kidney transplant patients was recorded in respective questionnaires after their examinations. Then, gingival enlargement and gingival index [GI] were divided into 4 degrees at 4 points and plaque index [PI] was recorded according to Oleary index. Finally, the obtained results were analyzed by means of SPSS Software [V:16], using Chi-square and T-Test

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Results: Seventy-five renal transplant patients [31 women and 44 men] with the mean age 43.18 years [age range 18-73years] participated in this study. Gingival enlargement was diagnosed in 50% of the patients that had used cyclosporine. The average dosage of the drug was 179.6 mg. The increased prevalence of gingival enlargement was observed in the maxilla rather than in the mandible and more in the anterior than in the posterior parts of the jaws. Gingival enlargement was significantly correlated with GI and PI [P=0.01 and P=0.03, respectively]

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Conclusion: PI and GI were higher in patients with gingival enlargement than patients without gingival enlargement. Thus, it is suggested that periodontal proper hygiene be done to prevent gingival enlargement