Anticonvulsant effect of guaifenesin against pentylenetetrazol-induced seizure in mice

ABSTRACT

Background: There have been some reports about the possible N-methyl-D-aspartate [NMDA] antagonist activity of Guaifenesin. As drugs with a similar structure to Guaifenesin [i.e. Felbamate] and those with NMDA antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether Guaifenesin has an anticonvulsant effect in an animal model of seizure