increased level of serum p53 in Hepatitis B-associated liver cirrhosis

ABSTRACT

Background: The ability of tumour suppressor protein p53 [P53] to regulate cell cycle processes can be modulated by hepatitis B virus [HBV]. While preliminary evidences indicates the involvement of protein-x of HBV [HBx] in altering p53 DNA binding, no further data have been accumulated for the significance of serum p53 in chronic hepatitis B virus infected patients