Anticonvulsant activity of some vanilloid receptor agonists

ABSTRACT

Vanilloid receptors 1 [VR 1], a group of transient receptor potential channels family was cloned in 1997. They were found to be a potential target for treatment of different acute and chronic pain disorder. Recently these receptors were reported to be involved in several pathological conditions. The present study aimed to investigate the potential anticonvulsant activity of five vanilloidal agonists [capsaicin, nonivamide, zingerone, dehydrozingerone and 6-gingerol]. Experimental animal model of pentylenetetrazole [PTZ] induced seizure was used to investigate the potential anticonvulsant activity of capsaicin, nonivamide, zingerone, dehydrozingerone and 6-gingerol. The data obtained showed that, all tested compounds [capsaicin, nonivamide, zingerone, dehydrozingerone and 6-gingerol] possess dose dependant anticonvulsant activity. The five vanilloidal agonists; capsaicin, nonivamide, zingerone, dehydrozingerone and 6-gingerol exhibit anticonvulsant activity and may find clinical application