Anticonvulsant and neuroprotective effects of the Acacia tortilis growing in KSA

ABSTRACT

In different region of Saudi Arabia Acacia tortilis [Fabaceae] is present but still the medicinal properties of Acacia tortilis have not been studied. However, in Zimbabwe different species of Acacia are already used for the treatment of convulsions and dizziness. In the present study, the anticonvulsant and neuroprotective effects of the Acacia tortilis, were evaluated by using different paradigms. For extraction, the leaves of acacia were blended with distilled water at 40°C and filtered. Two different doses of the extracts [400 and 800mg/kg] were administered in the mice once orally [p.o.] and after 30 min occurrence of seizures [strychnine at the dose of 1mg/kg, i.m.] were monitored. In the present work, acute toxicity and neurotoxicity of the extracts were also assessed by inducing hypoxic stress. The Acacia tortilis leaves AAq [400 and 800 mg/kg] produced a dose dependent increase in time of onset of seizures [197.8+/-32.4 and 338.2+/-40.6 respectively] when compared with its respective control [184.0+/-13.8sec]. The anticonvulsant effect after administration of AAq [800mg/kg 338.2+40.6 sec] was more pronounced than diazepam [290.6+/-1.38 sec]. The high dose [800mg/kg] of AAq administered orally prolonged the onset of convulsion and latencies for death following hypoxic stress. The present study suggested that Acacia have anticonvulsant property and may probably be affecting the inhibitory mechanism of glycine. It is also concluded that chemical constituent of acacia might act on BZD or 5-HT [1A]receptor and decrease the oxidative brain membrane damage process induced by psychological/hypoxic stress. Further experiments will be required to identify the active molecules [s] and their mechanism [s] of action