Intravenous lidocaine suppresses dexamethasone-induced perineal pruritus during anesthesia induction: a randomized controlled, double blind study
Pakistan Journal of Pharmaceutical Sciences. 2015; 28 (2): 569-572
en Inglés
| IMEMR
| ID: emr-178158
ABSTRACT
Previous studies have found that intravenous dexamethasone may produce perineal pruritus in some patients when administered as premedicant in the preoperative period. This randomized controlled, double-blind study evaluated the efficacy of pretreatment of lidocaine on the incidence and severity of dexamethasone-induced perineal pruritus. 400 patients were enrolled in this study and allocated randomly into four groups [n=100, in each]. Then, patients received intravenously anesthesia induction as the following sequence of medications injecting 0.9% sodium chloride [placebo] 10 mL in group I, lidocaine 0.5mg/kg in group II, lidocaine 1mg/kg in group III, and lidocaine 1.5mg/kg in group IV, 1 minute later, injecting 10mg dexamethasone in all groups. The severity of perineal pruritus was graded based on the VAS as none [VAS 0], mild [VAS 1-3], moderate [4-6], or severe [VAS 7 to 10], and recorded the occurrence, the severity and the duration of perineal pruritus. Occurrence of perineal pruritus was significantly reduced in group III and group IV [8%, 9% vs 40% and 33% in Groups I and II, respectively, p<0.05]. The incidence of perineal pruritus of females was higher than males in groups I and II [P<0.05]. The duration of perineal pruritus was shorter in group IV compared to groups I, II and III [p<0.05]. We conclude that pretreatment 1mg/kg or 1.5mg/kg lidocaine may effectively reduce the incidence of perineal pruritus
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Perineo
/
Prurito
/
Dexametasona
/
Método Doble Ciego
/
Administración Intravenosa
/
Anestesia
/
Anestesia Intravenosa
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Pak. J. Pharm. Sci.
Año:
2015
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