Role of angiotensin converting enzyme inhibitors [Ramipril] and angiotensin receptor blocker [Losartan] on microalbuminuria in diabetes mellitus type-II

ABSTRACT

All the patients included in the study were divided into three groups. Group A patients received Angiotensin converting enzyme inhibitor [Ramipril] for a period of six months, the urinary albumin decreased in them by 34.89% while group B patients received Angiotensin receptor blockers [Losartan] for the same period and urinary albumin decreased by 39.73%. The resistant cases of both the groups were included in group C and this group was given a combination of Angiotensin converting enzyme inhibitors and Angiotensin receptor blockers i.e., Ramipril and Losartan in these resistant cases the urinary albumin decreased by 35.8%. Angiotensin converting enzyme inhibitors, Angiotensin receptor blockers and combination of both are effective in reducing the excretion of albumin in diabetic patients having microalbuminuria. These drugs beneficially influence the altered glomerular haemodynamics in patients with diabetes mellitus the measurement of albuminuria can prevent the renal damage and that it is a modifiable risk factor