Formulation of aspirin tablets using fewer excipients by direct compression

ABSTRACT

The objective of the present study was to formulate aspirin tablets by direct compression method using fewer excipients and to compare this formulation with the other brands. Design formulation besides aspirin contained excipients that comprises of lactose, corn starch and aerosol. The blend was compressed on a single punch machine, tablets were subjected to various tests [uniformity of weights, diameter and thickness, hardness, disintegration, dissolution and assay of the drug] and the results were compared with some of the available brands. The studied formulation showed close resemblance with the available marketed brands and were also in compliance with the official specifications. Using the present approach, further studies should be designed using other actives and excipients to get a cost effective product