Vitex Agnus Castus extract improves learning and memory and increases the transcription of estrogen receptor alpha in hippocampus of ovariectomized rats

ABSTRACT

Introduction: Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormone-dependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitive decline