Detection of TET2, KRAS and CBL variants by Next Generation Sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML
Egyptian Journal of Medical Human Genetics [The]. 2016; 17 (2): 209-215
en Inglés
| IMEMR
| ID: emr-180240
ABSTRACT
Background:
Acute myeloid leukemia [AML] is a heterogeneous clonal disorder in terms of cytogenetic and molecular aberrations. Ten-Eleven-Translocation 2 [TET2], Kirsten rat sarcoma viral oncogene homolog [KRAS], and Casitas B-cell lymphoma [CBL] have an important role pathogenesis of acute myeloid leukemia [AML] and their activated mutations confer proliferative and survival signals
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Proteínas Proto-Oncogénicas p21(ras)
/
Proteínas Proto-Oncogénicas
/
Análisis de Secuencia de ADN
/
Proteínas de Unión al ADN
/
Proteínas Proto-Oncogénicas c-cbl
/
Tirosina Quinasa 3 Similar a fms
/
Janus Quinasa 2
Límite:
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Egypt. J. Med. Hum. Genet.
Año:
2016
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