Levels of myelin basic protein and its antibodies in the serum of the patients with neurological disease [autism, multiple sclerosis]

ABSTRACT

Myelin basic protein [MBP] is an important part of myelin sheets, and it's breakdown plays an important role in many nervous diseases, and it was thought that the destruction of MBP occur by the formation of MBP antibodies. So the aim of our study is to detect the differences of MBP and MBP-Abs levels between the patients with multiple sclerosis [MS], autism and epilepsy and apparently healthy controls. the study group involved 92 samples [32 patients with autism, 19 patients with MS, 20 patients with epilepsy, 21 controls], and the determination of MBP and MBP-Abs was achieved by the enzyme-linked immune sorbent assay [ELISA]. the ratio of MBP was higher in the patients with MS [53%], and autism [31%] than the patients with epilepsy [10%], and healthy control [5%]. the ratio of MBP-Abs was higher in the patients with MS [36%], and autism [38%] than the patients with epilepsy [15%] and healthy control [5%]. The presence of MBP or MBP-Abs in the patient's serum indicate to the presence of autoimmune problem and may help to direct the treatment