[ Mechanizm of Pain modulation in Rostarl-Ventromedial medulla]

ABSTRACT

Background: Several systems of pain modulation in the central nervous system modulated the responses to painful stimuli in stressful and excitement situations. Stimulation of the hypothalamus induces analgesia through information relay to the brain stem including Rostral- Ventromedial medulla. The Rostral-Ventromedial medulla as output gate of the brain stem medulated pain through neurons in the dorsal horn. This pain modulation in central nerous system in various psychological conditions was based on existing of different neural groups and the special connections between them. These neurons cause pain modulation. The functional relationship between activation of one group of them and increasing pain and activation of another group and reduction of pain has been observed. In this review, it is discussed about the role of different neural groups of rostral-ventromedial medulla in pain modulation.