Design and development of buccal mucoadhesive drug deliverysystem for perindopril

ABSTRACT

The main objective of present study was to develop a buccal mucoadhesive drug delivery system for perindopril.Perindopril buccal mucoadhesive patches were developed by solvent casting technique using hydroxy propylmethylcellulose [HPMC], polycarbophil, sodium carboxymethylcellulose [SCMC] and sodium alginate as polymersfor extended release of perindopril. Glycerine and DMSO were used as plasticizer and penetration enhancerrespectively. Ethanol, methanol and dichloromethane were used as solvents. FTIR and DSC studies revealed nointeraction between drug and polymers. The drug content in the perindopril patches was found to be uniform. The filmsexhibited good physical and mechanical properties. The surface pH of all the patches was within salivary pH range.Residual solvent content in patches are below the tolerated limits. The patches were found to have an extended releaseof the drug upto a period of 12 hours during ex vivo permeation studies with non-Fickian diffusion mechanism. Thepresent study demonstrated the possibility of designing a buccal drug delivery system for perindopril