Role of metal ions on the bactericidal properties of sulfonamide drugs Bactrim and Primox

ABSTRACT

Cobalt [II], copper [II], nickel [II] and zinc [II] metal complexes of sulfonamide drugs bactrim and primox have been synthesised. The pharmacological assay show that the metal atoms enhance the activity and potency of these drugs against a number of bacterial species such as streptococcus pneumoniae, staphylococcus aureus. escherichia coli, klebsiella pneumoniae and proteus vulgaris