Immunological status of the patients with brain tumours

ABSTRACT

To study the humoral immune response of the patients with brain tumours, estimation of glucose, immunoglobulins [lgG, lgA, IgM] and proteins electrophoresis was carried out on the sera of 37 patients of brain tumours. The findings were compared with the results obtained from 20 healthy controls matched for age, sex and socioeconomic status. There was no significant difference in levels of glucose, proteins and its fractions between patients and controls. Only Alpha-2 was higher among patients as compared to controls [P<0.05]. lgG and IgA were higher in controls than patients but the difference was not significant. However, all immunoglobulins were significantly high among patients with benign tumours as compared to those with malignant tumours. Our finding of suppressed serum lgG suggests that the malignant tumours of brain have some immunosuppressive effects