[Influence of some essential and non essential amino acids on plasma lipids and gamma glutamyl transferase [GGT] activity in rats]

ABSTRACT

Long-term administration of L-essential amino acids including isoleucine [Ile], leucine [leu] and valine [Val] to young rates for 70 consecutive days caused significant increase in plasma cholesterol triglycerides, LDL-cholesterol and total LDL and gammaGT activity, whereas Lysine [Lys] produced the same effects in these parameters but the plasma triglycerides were not changed. Administration of L-non-essential amino acids including arginine [Arg] cystine [Cys] and glycine [Gly] to another group of young rates did not affect cholesterol, triglycerides levels or [gamma GT] activity during the same period and under the same condition. Administration of glutamic acid [Glu] caused significant decreases in plasma cholesterol, LDL cholesterol and total LDL levels IIE, Leu, Val, Cys and Arg produced a significant decrease in HDL-cholesterol but Glu caused a significant increase. These results demonstrated that long-term feeding of pure L-essential amino acids caused a significant increase in plasma lipids along with plasma gamma GT activity of young rates. Furthermore, our result indicates that Glu causes reductions in plasma cholesterol levels, with its ability to protect the myocardium against insulting stimuli that precipitate ischemia and arrhythmias [31] may has therapeutic value in correcting hypercholesterolemia and improving cardiac performance