Imatinib alters cell viability but not growth factors levels in TM4 Sertoli cells

ABSTRACT

Background: The anticancer agent imatinib [IM] is a small molecular analog of ATP that inhibits tyrosine kinase activity of platelet derived growth factors [PDGFs] and stem cell factor [SCF] receptor in cancer cells. However these factors have a key role in regulating growth and development of normal Sertoli, Leydig and germ cells