DNA repair genes polymorphisms and risk of colorectal cancer in Saudi patients

ABSTRACT

Background and study aims: Polymorphisms in the DNA repair genes may influence individual capacity to repair DNA damage, which may be associated with increased genetic instability and carcinogenesis. Our aim was to evaluate the relation of genetic polymorphisms in 2 DNA repair genes, XPD Lys751Gln and XRCC1 [A399G], with colorectal cancer [CRC] susceptibility. We further investigated the potential effect of these DNA repair variants on clinicopathological parameters of CRC patients