Cell Journal [Yakhteh]. 2017; 18 (4): 485-492
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| IMEMR
| ID: emr-185774
ABSTRACT
Approximately 5-10% of all thyroid cancers are medullary thyroid carcinomas [MTC]. MTC is mainly sporadic in nature, but 20-30% of cases are hereditary. Genetic testing for hereditary MTC is very important for the patient and his family, but the patients must be receiving appropriate genetic counseling. About 98% of patients with hereditary MTC have germline mutations in exons 10, 11, 13, 14, 15, 16 and intron 16 of the REarrangement during transfection [RET] proto-oncogene, but the etiology of the more frequent sporadic form of MTC [sMTC] is not well understood. Recently, it has been reported that apparently sporadic MTC may involve point mutations in BRAF and RAS genes, with an overall prevalence of almost 10%. Also alteration and abnormal expression of miRNA has been described in MTC. In this review, we attempted to mention some mutations and molecular changes in sporadic and hereditary MTC pathogenesis
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Neoplasias de la Tiroides
/
Neoplasia Endocrina Múltiple Tipo 2a
/
MicroARNs
/
Proteínas Proto-Oncogénicas c-ret
/
Estudios de Asociación Genética
/
Patología Molecular
Límite:
Humanos
Idioma:
Inglés
Revista:
Cell J. [Yakhteh]
Año:
2017
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