Histopathological studies of the genital organs experimentally exposed to the sub-anesthetic doses of isoflurane and enflurane

ABSTRACT

Sixty adult albine rats were used in this experiment. They were divided into 3 groups each of 20, the first group was used as control. The second was exposed to the sub-pasaesthetic doses of isoflurane for 2 months. The third group was exposed to the subanaesthetic doses of enflurane for a month. At the end of the first and second months of exposure, the animals were sacrificed respectively for the histopathological examination of the genital organs. The histopathological changes of genital organs after one month exposure to isoflurane and enflurane were congested testicular blood vessels, congestion of epididymis, prostate, seminal vesicle, uterine blood vessels and focal uterine epithelial degeneration. The histopathological changes of genital organs after 2 months exposure were atrophy of semineferous tubules and prostatic acini, decreased seminal fluid, graafian cyst, degenerated ova, vacuolar degeneration of the uterine epithelial lining of rats exposed to isoflurane. While in rats exposed to enflurane there were aspermatogenesis, epithelial proliferation of prostatic acini and seminal vesicle, graafian cyst, degenerated ova, leucocytic infiltration and degenerated uterine glands