Evaluation of the protective effect of hydro-alcoholic extract of raspberry fruit on aquaporin1 expression in rats kidney treated by methotrexate

ABSTRACT

Objective: Methotrexate [MTX] is an antimetabolite drug commonly prescribed for the various cancers and autoimmune diseases. Despite its considerable therapeutic effects, nephrotoxicity is the most important side-effect of treatment with MTX. Aquaporin1 [AQP1] is a water channel proteins which is present in mammalian kidney. Raspberry fruit with antioxidant properties is able to protect biological systems from the harmful effects of free radicals. The purpose of this study was to investigate the effect of raspberry extract on expression of AQP1 and the MTX-induced nephrotoxicity in rats