Immunohistochemical identification of prostatic acid phosphatase, correlation of normal, hyperplastic and neoplastic prostate

Immunohistochemical demonstration of prostatic acid phosphatase in normal, hyperplastic and neoplastic human prostates were studied by immunocytochemical methods. In normal or hyperplastic prostates, the localization of prostatic specific acid phosphatase was uniformly observed at the apical portion of the glandular epithelium of apical cells under light microscopy. Light microscopic examination of neoplastic prostates revealed a more intense and uniform staining of tumour cells of glandular epithelium of well differentiated adeno-carcinoma, whereas less intense and more variable staining was seen in neoplastic cells of moderately and poorly differentiated adenocarcinoma. Among neoplastic cells, positive granules with less intensity were found between collagen fibres as well as the endothelium of the stromal capillaries in anaplastic tissue