Tinospora cordifolia induces cell cycle arrest in human oral squamous cell carcinoma cells
GJO-Gulf Journal of Oncology [The]. 2017; (24): 10-14
en Inglés
| IMEMR
| ID: emr-187526
ABSTRACT
Natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to drugs. Tinospora cordifolia [Guduchi] has been used for centuries in Ayurvedic system of medicine for treating various ailments including cancer. In present study, we found that the Tinospora cordifolia extracts [TCE] induced inhibition of proliferation of KB cells was associated with arrest of GO/G1-phase of cell cycle. The effectiveness of TCE in checking the growth of KB cells without altering the growth of normal peripheral blood mononuclear cells [PBMC] indicates that Tinospora cordifolia has differential effect on normal and malignant cells hence, it may have therapeutic potential in cancer
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Línea Celular Tumoral
/
Proliferación Celular
/
Puntos de Control del Ciclo Celular
Límite:
Humanos
Idioma:
Inglés
Revista:
Gulf J. Oncol.
Año:
2017
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