Hepatorenal function as influenced by contraceptives, diuretics and their combination

ABSTRACT

The effect of short acting drugs namely; Anovlar [an oral 1 contraceptive drug] and Chlorothiazide [diuretic agent] as well as long acting drugs namely; Deladroxate [DDX, an injectable estrogen progesterone combination] and Hygroton [Chlorthalidon, a long acting diuretic] and their combination on hepatorenal function was studied using adult female albino rats. The experimental period lasted for three months to study their effects on the level of total serum protein, albumin, globulin, SGOT, SGPT, alkaline phosphatase [AP], uric acid, urea, potassium and sodium. The data proved that contraceptive drugs induced marked increase in AP and urea levels, whereas the diuretic drugs induced marked increase on the level of uric acid and decrease of electrolytic balance. Meanwhile, the combined administration of the test drugs induced synergistic effect that could be interpreted as definite disturbances in the hepatorenal function of the test animals. The results obtained were statistically analyzed and discussed