Role of 5-HT[1] receptors of accumbens shell arena upon ACPA-induced anxiolytic-like behaviors in rat

ABSTRACT

Cannabinoids induce diverse responses on anxiolytic-like behaviors. Moreover some studies postulated that there is a close relationship between this system and serotonergic system upon cognitive process formation. Thus the aim of present study is investigation the possible role of 5-HT[1] receptor on anxiolytic-like behaviors induced by ACPA in the elevated plus maze task [EPM]. In the present study rats weighting 250-300g upon surgery bilateral guide cannulae were implanted to allow microinjection of ACPA [agonist CB1 receptor], CP94253 Hcl[agonist 5-HT[1] receptor] alone and them interaction in the AcbSh. The data showed pretest AcbSh infusion of ACPA at doses of0.0002, 0.002, 0.02 and 0.2 micro g/rat increased and decreased the percentage of open-arms time [%OAT] and percentage of Enclosed-arms time [%CAT], respectively as compared to control groups. Pretest AcbSh infusion ofCP94253 Hcl at doses of 5, 0.5 and 0.05 ng/rat, did not alter anxiety-like behaviors. In addition intra-AcbSh microinjection of subthreshold dose of CP94253 Hcl did not alter ACPA-induced anxiolytic-like behaviors. Our data suggest that activation of AcbSh 5-HT[1] receptor did not involve in ACPA-induced behaviors in the EPM task