NUCB2/Nesfatin-1: a potent meal regulatory hormone and its role in diabetes

ABSTRACT

Background: Nesfatin-1, a newly discovered calcium and DNA binding peptide, originate from nucle-obindin 2 [NUCB2] precursors and expressed by central and peripheral nervous system, and peripheral tissues such as digestive organs and adipose tissues. It has the astonishingly large number of chemical messengers for full appetite and introduced as a potential anorectic factor with ability to modulate body weight and probably, energy homeostasis