Susceptibility patterns of TB isolates from HIV-infected and non-HIV- infected tuberculous patients at king Abdulaziz university hospital, Jeddah, Kingdom Of Saudi Arabia

ABSTRACT

Tuberculosis [TB] is the most common opportunistic infection and leading cause of death in persons infected with human immunodeficiency virus [HIV] worldwide. HIV pandemic is one of the greatest challenges facing TB control program. Immune suppression by HIV- infection increases the risk of reactivation of latent TB infection and rapid progression of either recent or latent TB infection to active TB disease. Multidrug resistant- TB [MDR -TB] has been associated with inadequate and poor adherence to treatment regimens, poorly managed TB- control programs, as well as HIV- infection. Comparing the anti- tuberculous drug resistance patterns of Mycobacterium tuberculosis complex [MBTC] isolates from HIV-seropositive and HIV- seronegative TB patients attending King Abdulaziz University Hospital [KAAU], Jeddah, KSA, from January 2011 till January 2013. A total of [132] TB patients were included, they were divided into 31[23.48%] patients with HIV- infection [51.60% males and 48.40% females]and 101[76.52%] patients without HIV- infection [40.60% males and 59.40% females]