Expression of hsa-MIR-204, RUNX2, PPAR gamma, and BCL2 in bone marrow derived mesenchymal stem cells from multiple myeloma patients and normal individuals
Cell Journal [Yakhteh]. 2017; 19 (Supp. 1): 27-36
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| IMEMR
| ID: emr-189337
ABSTRACT
Objective:
Multiple Myeloma [MM] is a heterogeneous cytogenetic disorder in which clonal plasma cells proliferate in the bone marrow [BM] and cause bone destruction. The BM microenvironment plays a crucial role in pathogenesis of this disease, and mesenchymal stem cells [MSCs] are one of the key players. Herein, we propose to investigate the expressions of hsa-MIR-204, runt-related transcription factor 2 [RUNX2], peroxisome proliferator-activated receptor gamma [PPAR gamma], and B-cell lymphoma 2 [BCL2] as factors involved in osteogenesis, adipogenesis, and MSC survival in BM-MSCs from MM patients and normal individuals
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Osteogénesis
/
Médula Ósea
/
Proteínas Proto-Oncogénicas c-bcl-2
/
MicroARNs
/
PPAR gamma
/
Subunidad alfa 1 del Factor de Unión al Sitio Principal
/
Adipogénesis
/
Células Madre Mesenquimatosas
Límite:
Anciano
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Cell J. [Yakhteh]
Año:
2017
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