Effect of different doses of pregabalin on erythrocyte deformability in rats with lower limb ischemia reperfusion injury

ABSTRACT

Background and Objective: Acute ischemia reperfusion [IR] injury observed in the lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Preoperative pregabalin has been used as a part of multimodal analgesia in postoperative pain treatment in recent years. Pregabalin has become one of the increasingly common agents in postoperative analgesia. In this study, we aimed to investigate the effect of pregabalin on erythrocyte deformability in rats undergoing IR