[Effect of valproic acid on Expression of Bim gene and viability of ovarian cancer cell line A2780]
Journal of Gorgan University of Medical Sciences. 2017; 18 (4): 60-66
en Inglés, Persa
| IMEMR
| ID: emr-189605
ABSTRACT
Background and Objective:
Ovarian cancer is the fifth common cancer among women and the number of new cases is increasing. Valproic acid is a histone deacetylase inhibitor effectively used to treat epilepsy and bipolar disease. Recently, this compound has attracted attention as an anti-cancer agent. Bim is one of the most important genes of mitochondrial pathway of apoptosis, and it plays an important role in the biology of cancer. Expression of this gene is greatly reduced in ovarian cancer. This study was done to evaluate the effect of valproic acid on the viability of ovarian cancer cells, apoptosis and Bim gene expression in A2780 line
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Neoplasias Ováricas
/
Supervivencia Celular
/
Apoptosis
/
Línea Celular Tumoral
/
Citometría de Flujo
/
Proteína 11 Similar a Bcl2
Tipo de estudio:
Estudio de incidencia
Límite:
Humanos
Idioma:
Inglés
/
Persa
Revista:
J. Gorgan Univ. Med. Sci.
Año:
2017
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